Complex networks approach to study comorbidities in patients with unruptured intracranial aneurysms.

The role of complex network analysis in patients with diagnosis of unruptured intracranial aneurysm is unexplored. The objective of this study is to assess the applicability of this methodology in aneurysm patients. We retrospectively analyze comprehensive unbiased local digital data of a large number of patients treated for any reason between January 2004 and July 2019. We apply an age-cohort approach to a total of 628,831 patients and construct the diagnostic history of each patient-and include the information how old the patient was when diagnosed for the first time with each diagnosis coded according to International Classification of Diseases. For each cohort of age within a 10 year interval and for each gender, we construct a statistically validated comorbidity network and focused on crucial comorbidity links that the aneurysm code has to other disease codes within the whole network. For all cohorts of different age and gender, the analysis shows that 267 diagnose codes have nearest neighbour statistically validated links to unruptured aneurysm ICD code. Among the 267 comorbidities, 204 (76%) were found in patients aged from 40 to 69-years old. Patterns of connectivity with aneurysms were found for smoking, hypertension, chronic obstructive pulmonary disease, dyslipidemia, and mood disorders. A few uncommon connections are also detected in cohorts of female patients. Our study explored the applicability of network analysis and statistical validation in aneurysm observational study.

Agta hunter-gatherer oral microbiomes are shaped by contact network structure.

Here we investigate the effects of extensive sociality and mobility on the oral microbiome of 138 Agta hunter-gatherers from the Philippines. Our comparisons of microbiome composition showed that the Agta are more similar to Central African BaYaka hunter-gatherers than to neighbouring farmers. We also defined the Agta social microbiome as a set of 137 oral bacteria (only 7% of 1980 amplicon sequence variants) significantly influenced by social contact (quantified through wireless sensors of short-range interactions). We show that large interaction networks including strong links between close kin, spouses and even unrelated friends can significantly predict bacterial transmission networks across Agta camps. Finally, we show that more central individuals to social networks are also bacterial supersharers. We conclude that hunter-gatherer social microbiomes are predominantly pathogenic and were shaped by evolutionary tradeoffs between extensive sociality and disease spread.

The making of the oral microbiome in Agta hunter-gatherers.

Ecological and genetic factors have influenced the composition of the human microbiome during our evolutionary history. We analysed the oral microbiota of the Agta, a hunter-gatherer population where some members have adopted an agricultural diet. We show that age is the strongest factor modulating the microbiome, probably through immunosenescence since we identified an increase in the number of species classified as pathogens with age. We also characterised biological and cultural processes generating sexual dimorphism in the oral microbiome. A small subset of oral bacteria is influenced by the host genome, linking host collagen genes to bacterial biofilm formation. Our data also suggest that shifting from a fish/meat diet to a rice-rich diet transforms their microbiome, mirroring the Neolithic transition. All of these factors have implications in the epidemiology of oral diseases. Thus, the human oral microbiome is multifactorial and shaped by various ecological and social factors that modify the oral environment.

Analysis of the Structure and Dynamics of European Flight Networks.

We analyze structure and dynamics of flight networks of 50 airlines active in the European airspace in 2017. Our analysis shows that the concentration of the degree of nodes of different flight networks of airlines is markedly heterogeneous among airlines reflecting heterogeneity of the airline business models. We obtain an unsupervised classification of airlines by performing a hierarchical clustering that uses a correlation coefficient computed between the average occurrence profiles of 4-motifs of airline networks as similarity measure. The hierarchical tree is highly informative with respect to properties of the different airlines (for example, the number of main hubs, airline participation to intercontinental flights, regional coverage, nature of commercial, cargo, leisure or rental airline). The 4-motif patterns are therefore distinctive of each airline and reflect information about the main determinants of different airlines. This information is different from what can be found looking at the overlap of directed links.

High-frequency trading and networked markets.

Financial markets have undergone a deep reorganization during the last 20 y. A mixture of technological innovation and regulatory constraints has promoted the diffusion of market fragmentation and high-frequency trading. The new stock market has changed the traditional ecology of market participants and market professionals, and financial markets have evolved into complex sociotechnical institutions characterized by a great heterogeneity in the time scales of market members' interactions that cover more than eight orders of magnitude. We analyze three different datasets for two highly studied market venues recorded in 2004 to 2006, 2010 to 2011, and 2018. Using methods of complex network theory, we show that transactions between specific couples of market members are systematically and persistently overexpressed or underexpressed. Contemporary stock markets are therefore networked markets where liquidity provision of market members has statistically detectable preferences or avoidances with respect to some market members over time with a degree of persistence that can cover several months. We show a sizable increase in both the number and persistence of networked relationships between market members in most recent years and how technological and regulatory innovations affect the networked nature of the markets. Our study also shows that the portfolio of strategic trading decisions of high-frequency traders has evolved over the years, adding to the liquidity provision other market activities that consume market liquidity.

Elites, communities and the limited benefits of mentorship in electronic music.

While the emergence of success in creative professions, such as music, has been studied extensively, the link between individual success and collaboration is not yet fully uncovered. Here we aim to fill this gap by analyzing longitudinal data on the co-releasing and mentoring patterns of popular electronic music artists appearing in the annual Top 100 ranking of DJ Magazine. We find that while this ranking list of popularity publishes 100 names, only the top 20 is stable over time, showcasing a lock-in effect on the electronic music elite. Based on the temporal co-release network of top musicians, we extract a diverse community structure characterizing the electronic music industry. These groups of artists are temporally segregated, sequentially formed around leading musicians, and represent changes in musical genres. We show that a major driving force behind the formation of music communities is mentorship: around half of musicians entering the top 100 have been mentored by current leading figures before they entered the list. We also find that mentees are unlikely to break into the top 20, yet have much higher expected best ranks than those who were not mentored. This implies that mentorship helps rising talents, but becoming an all-time star requires more. Our results provide insights into the intertwined roles of success and collaboration in electronic music, highlighting the mechanisms shaping the formation and landscape of artistic elites in electronic music.